Ellen took their blood pressure and temperature, including Maria's, even though she protested mildly, half in Spanish-a sign of how unsettling it was to her. Ellen had only just finished putting all the numbers on clipboard charts for each of them when Karl Van de Vliet opened the door and strode in.
Chapter 13
He had a high forehead and prominent cheekbones, just like in the photo. And just as in his photo, there was a genuine dichotomy between his face, which looked to be early forties and unwrinkled, and his gray eyes, which were much older. That was it. That was what seemed odd. He was different ages.
Underneath his white lab coat he was wearing a black suit and an open-necked blue shirt. Ally noticed that his fingers were long and delicate, like those of a concert pianist, and overall he had a kind of ghostly presence, as though he were more spirit than man. Although he looked exactly as he did in the photograph in the Gerex Corporation brochure, in person there was an added dimension, a kind of raw magnetism about him. It was more than simply a physician's bedside manner, it was the allure of a pied piper. The first thing you wanted to ask him was How old
What had she expected? Maybe a self-absorbed nerd researcher in wrinkled stained lab attire, anxious to scurry back to his test tubes. But in person Karl Van de Vliet was debonair and youthful, living proof that his photo wasn't retouched and was recent. He had to be twenty years older than she was, easily, but to look at him you'd guess he was close to the same age. She was dying to ask him about that but she couldn't think of a polite way to raise the subject.
She introduced herself. 'We spoke yesterday.' Then she introduced her mother and Maria. 'Mom and I talked last night about the clinical trials, and she said she's interested. This morning, unfortunately, I'm not sure she remembers what we discussed.'
He placed a hand on Nina's shoulder and studied her face as he smiled at her, embracing her with his eyes. 'Well, we're going to see what we can do about that aren't we, Mrs. Hampton?'
'I've got a question right up front' Ally said. 'Have we already been entered into the National Institutes of Health clinical trials?'
He seemed taken aback for a moment, caught off guard, but then he stepped up to the question.
'As a matter of fact I did take the liberty of authorizing the preliminary NIH paperwork for both of you. Of course it doesn't obligate you in any way. The thing is, there's a lot of red tape, so if you do decide to participate, the sooner we get that part started the better. On the other hand, if you decide not to, we can just terminate everything at this preliminary stage and you won't even be part of the official record.'
He focused on Nina. 'Mrs. Hampton, I'm Dr. Van de Vliet. You're a pretty lady, and we've had some luck helping other ladies like you.'
'Honey, if I had you in my bedroom, then maybe you could help me.'
OMG, Ally thought, she's about to go ribald on us. But that's a sign she's coming out of her funk.
But then she had another thought. Maybe Nina sensed he was older than he looked. Like that paranormal perception that told her Grant was involved in something evil. So far, however, that particular perception hadn't panned out (though Grant clearly was up to
Maria was mortified. She blushed and made a disapproving animal noise low in her throat and turned her face away, but Van de Vliet simply smiled even more broadly.
'Mrs. Hampton, I don't think you should be talking that way in front of your daughter.' He gave her a wink. 'What you and I do together is none of these people's business. But I do think we should consider keeping them informed if only a couple of hints.'
Ally found herself wanting just to listen to his voice. There was an intelligent warmth about it that reminded her of a kindly professor at Columbia, a truly gifted architect who also could quote Keats and make you cry. You wanted to give yourself to him. My God, she thought, how am I going to stand up to this man?
'There're some issues you and I need to discuss,' he said turning back to Ally. 'The first thing I need to do is take a look at Mrs. Hampton’s records. But whatever they say, it won't do any harm to run what we call a 'mental state examination' for her, to establish a general baseline of cognitive impairment as of now.'
'How long will that take?'
'Actually, Ellen can start in just a few minutes,' he said 'Of course, we'll need to hear about the usual danger signs everybody knows. Does Mrs. Hampton have recent-memory loss? Does she get confused about places and people? Does she have trouble handling money and paying her bills?'
'The short answer is yes.'
All of those things, Ally knew, had accelerated in the last six months. It was the tragic, recognizable onset of the latter stages of Alzheimer's. Already more than once Maria had said there were times when she didn't think Nina recognized her. More and more she seemed to be confused, unable some days to find her way around the apartment, and she'd started repeating herself. She often had trouble finding the right words, and she was increasingly paranoid and suspicious. Maria, who had worked with other Alzheimer’s patients, feared she might begin hallucinating soon, seeing things that weren't there.
Ally turned to her. It felt obscene to talk about her when she was sitting right there with them.
'Mom, sweetie, do you understand what Dr. Van de Vliet is asking? Do you think you have trouble doing everyday things?'
She knew the answer but she was determined that her mother not be treated like a potted plant.
'Ally, you know that half the time I can't remember a blessed thing. I'm getting crazy as a bloody coot.'
Then Nina turned and looked Van de Vliet in the eye.
'I don't want to lose my mind, Doctor. I don't want to see the shade closing in. I can't do crosswords anymore. I used to do them all the time. And all the music I used to know. It was my love and now. . now I can't tell Scriabin from Strauss half the time. It wasn't supposed to happen that way. I thought my mind would go on forever.'
'Mrs. Hampton, if you'll let me, what I want to do is try to work on your recollection. I don't know how much I can help you with crosswords, but then I've never been much good at them myself either. Your memory of music should improve, though. There are no guarantees, but-'
'Then I'm ready to try it, Doctor,' she cut in. 'You're all that stands between me and losing the only thing I have left, my past' Next came a burst of rationality. 'Now, I hate to be a pest but could you explain what exactly it is you're going to do. I want Ally to hear this too and then maybe she can go over it with me later and help me understand it.'
He smiled and reached over and stroked her slightly thinning hair. 'I'd be happy to try, Mrs. Hampton. It's actually pretty simple.'
Then he turned to Ally. 'We touched on some of this on the phone. Do you want to hear it again?'
'Yes, I'm still trying to get it all into my simple mind.'
'Well,' he began, 'to go back to the very beginning of my interest in stem cells the focus of our research has been directed toward challenging the notorious Hayflick limit. Back in the 1960s, Professor Leonard Hayflick discovered that when tissue cells are taken from the body and cultured in a laboratory dish, those cells grow and divide about fifty times, give or take, and then they stop. They have reached old age, senescence. The physical basis of the Hayflick limit is a section of DNA known as telomere, which gets shorter each time the cell divides. Eventually the telomeres become so short that all cell division stops. It's like an internal clock telling them the game is over. They've had their innings.'
'And you're saying you've found a way to beat the clock, to stop the telomeres from getting shorter?'
'All cells possess a gene known as the telomerase gene, which can restore the telomeres to their youthful
