“Anything wrong, sir?” the desk clerk inquired politely.

Smith looked around. “Nothing. Nothing at all. Well, better be on my way if I want to catch the next seminar.”

He stuffed the note into his trench-coat pocket and strode out into the soggy afternoon. How had Bill known he was in London? At this particular secluded hotel? And why all the cloak-and-dagger, even to the extent of using Bill's private boyhood name for him?

No return address or phone number.

Only an initial to identify the sender.

Why midnight?

Smith liked to think of himself as a simple man, but he knew the truth was far from that. His career showed the reality. He had been a military doctor in MASH units and was now a research scientist. For a short time he had also worked for military intelligence. And then there was the stint commanding troops. He wore his restlessness like another man wore his skin ? so much a part of him he hardly noticed.

Yet in the past year he had discovered a happiness that had given him focus, a concentration he had never before achieved. Not only did he find his work at USAMRIID challenging and exciting, the confirmed bachelor was in love. Really in love. No more of that high-school stuff of women coming and going through his life in a revolving door of drama. Sophia Russell was everything to him ? fellow scientist, research partner, and blond beauty.

There were moments when he would take his eyes from his electron microscope just to stare at her. How all that fragile loveliness could conceal so much intelligence and steely will constantly intrigued him. Just thinking about her made him miss her all over again. He was scheduled to fly out of Heathrow tomorrow morning, which would give him just enough time to drive home to Maryland and meet Sophia for breakfast before they had to go into the lab.

But now he had this disturbing message from Bill Griffin.

All his internal alarms were ringing. At the same time, it was an opportunity. He smiled wryly at himself. Apparently his restlessness still was not tamed.

As he hailed a taxi, he made plans.

He would change his flight tickets to Monday night and meet Bill Griffin at midnight. He and Bill went too far back for him to do otherwise. This meant he would not get into work until Tuesday, a day late. Which would make Kielburger, the general who directed USAMRIID, see red. To put it mildly, the general found Smith and his freewheeling, field-operations way of doing things aggravating.

Not a problem. Smith would do an end run.

Early yesterday morning he had phoned Sophia just to hear her voice. But in the middle of their conversation, a call had cut in. She had been ordered to go to the lab immediately to identify some virus from California. Sophia could easily work the next sixteen or twenty-four hours nonstop and, in fact, she might be at the lab so late tonight, she would not even be up tomorrow morning, when he had been planning to share breakfast. Smith sighed, disappointed. The only good thing was she would be too busy to worry about him.

He might as well just leave a message on their answering machine at home that he would arrive a day late and she should not be concerned. She could tell General Kielburger or not, her call.

That was where the payoff came in. Instead of leaving London tomorrow morning, he would take a night flight. A few hours' difference, but a world to him: Tom Sheringham was leading the U.K. Microbiological Research Establishment team that was working on a potential vaccine against all hantaviruses. Tonight he would not only be able to attend Tom's presentation, he would twist Tom's arm to join him for a late dinner and drinks. Then he would pry out all the inside, cutting-edge details Tom was not ready to make public and wangle an invitation to visit Porton Down tomorrow before he had to catch his night flight.

Nodding to himself and almost smiling, Smith leaped over a puddle and yanked open the back door of the black-beetle taxi that had stopped in the street. He told the cabbie the address of the WHO conference.

But as he sank into the seat, his smile disappeared. He pulled out the letter from Bill Griffin and reread it, hoping to find some clue he had missed. What was most noteworthy was what was not said. The furrow between his brows deepened. He thought back over the years, trying to figure out what could have happened to make Bill suddenly contact him this way.

If Bill wanted scientific help or some kind of assistance from USAMRIID, he would go through official government channels. Bill was an FBI special agent now, and proud of it. Like any agent, he would request Smith's services from the director of USAMRIID.

On the other hand, if it were simply personal, there would have been no cloak-and-dagger. Instead, a phone message would have been waiting at the hotel with Bill's number so Smith could call back.

In the chilly cab, Smith shrugged uneasily under his trench coat. This meeting was not only unofficial, it was secret. Very secret. Which meant Bill was going behind the FBI. Behind USAMRIID. Behind all government entities… all apparently in the hopes of involving him, too, in something clandestine.

CHAPTER TWO

9:57 A.M., Sunday, October 12 Fort Detrick, Maryland

Located in Frederick, a small city surrounded by western Maryland's green, rolling landscape, Fort Detrick was the home of the United States Army Medical Research Institute for Infectious Diseases. Known by its initials, USAMRIID, or simply as the Institute, it had been a magnet for violent protest in the 1960s when it was an infamous government factory for developing and testing chemical and biological weapons. When President Nixon ordered an end to those programs in 1969, USAMRIID disappeared from the spotlight to become a center for science and healing.

Then came 1989. The highly communicable Ebola virus appeared to have infected monkeys dying at a primate quarantine unit in Reston, Virginia. USAMRIID's doctors and veterinarians, both military and civilian, were rushed to contain what could erupt into a tragic human epidemic.

But better than containment, they proved the Reston virus to be a genetic millimeter different from the extremely lethal strains of Ebola Zaire and Ebola Sudan. Most important was that the virus was harmless to people. That exciting discovery skyrocketed USAMRIID scientists into headlines across the nation. Suddenly, Fort Detrick was again on people's minds, but this time as America's foremost military medical research facility.

In her USAMRIID office, Dr. Sophia Russell was thinking about these claims to fame, hoping for inspiration as she waited impatiently for her telephone call to reach a man who might have some answers to help resolve a crisis she feared could erupt into a serious epidemic.

Sophia was a Ph.D. scientist in cell and molecular biology. She was a leading cog in the worldwide wheels set in motion by the death of Maj. Keith Anderson. She had been at USAMRIID for four years, and like the scientists in 1989, she was fighting a medical emergency involving an unknown virus. Already she and her contemporaries were in a far more precarious position: This virus was fatal to humans. There were three victims ? the army major and two civilians ? all of whom had apparently died abruptly of acute respiratory distress syndrome (ARDS) within hours of one another.

It was not the timing of the deaths or the ARDS itself that had riveted USAMRIID; millions died of ARDS each year around the planet. But not young people. Not healthy people. Not without a history of respiratory problems or other contributing factors, and not with violent headaches and blood-filled chest cavities.

Now three cases in a single day had died with identical symptoms, each in a different part of the country ? the major in California, a teenage girl in Georgia, and a homeless man in Massachusetts.

The director of USAMRIID ? Brig. Gen. Calvin Kielburger ? was reluctant to declare a worldwide alert on the basis of three cases they had been handed only yesterday. He hated rocking the boat or sounding like a weak alarmist. Even more, he hated sharing credit with other Level Four labs, especially USAMRIID's biggest rival, Atlanta's Centers for Disease Control.

Meanwhile, tension at USAMRIID was palpable, and Sophia, leading a team of scientists, kept working.

She had received the first of the blood samples by 3:00 A.M. Saturday and had immediately headed to her Level Four lab to begin testing. In the small locker room, she had removed her clothes, watch, and the ring Jon

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