precious about dust mites and cat hairs. Today, it is kept less busy and gets up to mischief instead. This theory rests on a slightly dubious assumption about the ways in which the body's immune system works, but it has quite a lot of support. There is 7 0 G E N O M E
no dose of hay fever that a good tapeworm cannot cure, but then which would you rather have?
Another theory holds that the connection with urbanisation is actually a connection with prosperity. Wealthy people stay indoors, heat their houses and sleep on feather pillows infested with dust mites. Yet another theory is based on the undoubted fact that mild, casual-contact viruses (things like common colds) are increasingly common in societies with rapid transport and compulsory education.
Schoolchildren harvest new viruses from the playground at an alarming rate, as every parent knows. When nobody travelled much, the supply of new viruses soon ran out, but today, with parents jetting off to foreign lands or meeting strangers at work all the time, there is an endless supply of new viruses to sample at the saliva-rich, germ-amplifying stations we call primary schools. Over 200 different kinds of virus can cause what is collectively known as the common cold. There is a definite connection between childhood infection with mild viruses, such as respiratory syncitial virus, and asthma susceptibility. The latest vogue theory is that a bacterial infection, which causes non-specific urethritis in women and has been getting commoner at roughly the same rate as asthma, may set up the immune system in such a way that it responds aggressively to allergens in later life. Take your pick. My favourite theory, for what it is worth, is the hygiene hypothesis, though I wouldn't go to the stake for it. The one thing you cannot argue is that asthma is on the increase because 'asthma genes' are on the increase. The genes have not changed that quickly.
So why do so many scientists persist in emphasising that asthma is at least partly a 'genetic disease'? What do they mean? Asthma is a constriction of the airways, which is triggered by histamines, which are in turn released by mast cells, whose transformation is triggered by their immunoglobulin-E proteins, whose activation is caused by the arrival of the very molecule to which they have been sensitised.
It is, as biological chains of cause and effect go, a fairly simple concatenation of events. The multiplicity of causes is effected by the design of immunoglobulin E, a protein specially designed to E N V I R O N M E N T 7 1
come in many forms, any one of which can fit on to almost any outside molecule or allergen. Although one person's asthma may be triggered by dust mites and another's by coffee beans, the underlying mechanism is still the same: the activation of the immunoglobulin-E
system.
Where there are simple chains of biochemical events, there are genes. Every protein in the chain is made by a gene, or, in the case of immunoglobulin E, two genes. Some people are born with, or develop, immunological hair- triggers, presumably because their genes are subtly different from those of other people, thanks to certain mutations.
That much is clear from the fact that asthma tends to run in families (a fact known, incidentally, to the twelfth-century Jewish sage of Cordoba, Maimonides). In some places, by accident of history, asthma mutations are unusually frequent. One such place is the isolated island of Tristan da Cunha, which must have been populated by descendants of an asthma-susceptible person. Despite a fine maritime climate, over twenty per cent of the inhabitants have overt symptoms of asthma. In 1997 a group of geneticists funded by a biotechnology company made the long sea voyage
Find those mutant genes and you have found the prime cause of the underlying mechnanism of asthma and with it all sorts of possibilities for a cure. Although hygiene or dust mites can explain why asthma is increasing on average, only differences in genes may explain why one person in a family gets asthma and another does not.
Except, of course, here for the first time we encounter the difficulty with words like 'normal' and 'mutant'. In the case of alkaptonuria it is pretty obvious that one version of the gene is normal and the other one is 'abnormal'. In the case of asthma, it is by no means so obvious. Back in the Stone Age, before feather pillows, an immune system that fired off at dust mites was no handicap, because dust mites were not a pressing problem in a temporary 7 2 G E N O M E
hunting camp on the savannah. And if that same immune system was especially good at killing gut worms, then the theoretical 'asthmatic'
was normal and natural; it was the others who were the abnormals and
'mutants' since they had genes that made them more vulnerable to worm infestations. Those with sensitive immunoglobulin-E systems were probably more resistant to worm infestations than those without. One of the dawning realisations of recent decades is just how hard it is to define what is 'normal' and what is mutant.
In the late 1980s, off went various groups of scientists in confident pursuit of the 'asthma gene'. By mid-1998 they had found not one, but fifteen. There were eight candidate genes on chromosome 5
alone, two each on chromosomes 6 and 12, and one on each of chromosomes 11, 13 and 14. This does not even count the fact that two parts of immunoglobulin E, the molecule at the centre of the process, are made by two genes on chromosome 1. The genetics of asthma could be underwritten by all of these genes in varying orders of importance or by any combination of them and others, too.
Each gene has its champion and feelings run high. William Cookson, an Oxford geneticist, has described how his rivals reacted to his discovery of a link between asthma-susceptibility and a marker on chromosome 11. Some were congratulatory. Others rushed into print contradicting him, usually with flawed or small sample sizes.
One wrote haughty editorials in medical journals mocking his 'logical disjunctions' and 'Oxfordshire genes'. One or two turned vitriolic in their public criticism and one anonymously accused him of fraud.
(To the outside world the sheer nastiness of scientific feuds often comes as something of a surprise; politics, by contrast, is a relatively polite affair.) Things were not improved by a sensational story exaggerating Cookson's discovery in a Sunday newspaper, followed by a television programme attacking the newspaper story and a com- plaint to the broadcasting regulator by the newspaper. 'After four years of constant scepticism and disbelief, says Cookson mildly,2
'we were all feeling very tired.'
This is the reality of gene hunting. There is a tendency among E N V I R O N M E N T 7 3
ivory-towered moral philosophers to disparage such scientists as gold-diggers seeking fame and fortune. The whole notion of 'genes for' such things as alcoholism and schizophrenia has been mocked, because such claims have often been later retracted. The retraction is taken not as evidence against that genetic link but as a condemnation of the whole practice of seeking genetic links. And the critics have a point. The simplistic headlines of
