the only thing abnormal was the temperature.
“They’re both in bad shape, especially considering how quickly the illness came on,” Springer added.
“What antibiotic are they on?” As Pia knew from her studies with Rothman, there was debate about which was the best to use in serious salmonella cases.
“That’s a good question,” Dr. Springer said. “Actually Dr. Rothman briefed me recently on findings he had made in his studies of antibiotic sensitivity on these zero-gravity strains. All three strains he was working on are very sensitive to chloramphenicol. That’s an antibiotic that at one time was considered the best choice for typhoid, but it went out of favor in the seventies because newer strains of salmonella were becoming resistant. Dr. Rothman said that because these strains were grown in space, they were more virulent but somehow they’d also lost their chloramphenicol resistance. He was interested because drug resistance is a big problem with salmonella.”
“Have you thought of trying ceftriaxone?” Pia asked, referring to a newer antibiotic.
Springer hesitated, giving Pia a once-over look. He’d been trying to be nice to her, as she was obviously concerned about her mentor. When he resumed speaking his voice and syntax had changed. There was an edge. “I actually wasn’t requesting a consult by speaking with you. It’s purely as a courtesy that I’m filling you in on Dr. Rothman’s condition and course of treatment. But to answer your question, if it was a question, there is some sensitivity to ceftriaxone but significantly less than there is to chloramphenicol.”
“Chloramphenicol can cause aplastic anemia,” Pia said, missing Springer’s signal that she was pushing it.
“Yes, we’ve taken into account the side effects, of course. Excuse me.” Springer suddenly got to his feet. Abruptly he left Pia, talked briefly with one of the residents helping with Rothman’s and Yamamoto’s care, then left the floor.
Pia waited for a few minutes before wandering over to the same resident, who was reading a chart.
“What do you think of Dr. Springer? Do you think he’s qualified?”
“What do I think? He’s the best in the country. I wouldn’t be here otherwise.”
Puzzled by the question, the resident walked away, leaving Pia standing by the nurses’ station, alone.
27.
COLUMBIA UNIVERSITY MEDICAL CENTER NEW YORK CITY MARCH 23, 2011, 7:38 P.M.
News of the Rothman/Yamamoto event spread rapidly through the Columbia medical community. George Wilson, like everyone else, had heard about it, and he could only imagine the effect it was having on Pia. Concerned, he had looked for her. It took some searching but George finally managed to track her down. She didn’t answer her cell phone and neither Will nor Lesley had seen her, so he had had to physically find her. George struck gold in the library stacks, a place he knew she found comforting. After some cajoling, Pia agreed to go with him back to the dorm cafeteria.
Pia was as distraught as she could ever remember being. She was especially upset because her emotions were so conflicted. Usually in her tumultuous life, distress had a definitive cause, but now she didn’t know whether to be upset about Rothman’s dire condition or angry at his carelessness in getting infected with the bacteria he’d been working on. And there was an undercurrent: Pia was terrified about her own future, which she thought she’d been so careful about but now seemed to be in the balance. She was also furious with herself for allowing Rothman to penetrate her well-constructed protective shell. And now she had the added distraction of George, who was trying to be solicitous but making things worse with all his questions.
“I can’t sit here anymore,” Pia said suddenly, interrupting George, but she didn’t care.
“You haven’t eaten anything,” George said, looking down at her tray. “You’ve got to eat.”
“I can’t eat,” Pia complained. “Feeling I’m in control is important to me. I don’t feel in control. My life is coming apart. I’ve got to see Rothman. I have to.”
Security was essential to Pia, as was control. At the moment she felt neither.
“Is he allowed to have visitors?”
“I don’t even know if he’s conscious. But I’m not a visitor, I’m concerned about the course of treatment he’s on.”
“I’ll come with you,” George said.
Pia didn’t know whether she wanted him to come or not.
“Don’t you have things to do?”
“Nothing important. I want to help you.”
“Whatever!”
Pia jumped up from the table, leaving her tray of food untouched. George stuck her turkey sandwich, still in its wrapper, in his jacket pocket and hustled after Pia. As she marched to the hospital, George trailed along in her wake. He tried to talk to her but gave up when she wouldn’t answer. She was on a mission.
The floor housing Rothman and Yamamoto was bustling with staff and orderlies. There were few patients in evidence. Most were too sick to be up and about. Pia found the resident on duty, Dr. Sathi De Silva. As the sole infectious disease resident, she had her hands full, not just with her two celebrity patients but a ward full of others, and several more people in the emergency room awaiting her attention. Pia and George were in their medical school white coats so Dr. De Silva accepted them as students most likely on their internal medicine rotation. Dr. De Silva took her teaching responsibilities very seriously, so when Pia started asking questions about Dr. Rothman, she stopped what she was doing. “To answer your question, both Dr. Rothman and Dr. Yamamoto are dangerously ill. They’re both delirious and uncommunicative.”
“I understand they’re on chloramphenicol. What’s your feeling about such a choice?”
Dr. De Silva shrugged. “I think it’s a good choice. Yes. It’s a unique situation because there are newer antibiotics, but in this case we have sensitivity studies that show the involved strains of salmonella to be uniquely sensitive. Dr. Springer believes it’s our best hope. We’re monitoring for side effects, but we haven’t seen anything. If there are any problems, we can always switch to one of the newer, third-generation cephalosporins.”
“Strange case,” Pia commented.
“One of the strangest,” Dr. De Silva agreed. “And not a little ironic.”
“Do we know how they got infected?”
“If we do, I haven’t heard anything. I know the CDC epidemiologists went through the lab and particularly the level-three containment area where the salmonella strain was kept. I think their initial concerns were about a malfunction of the hood, but apparently it was working fine. There was some bacteria in the hood itself, but you’d expect that. They took cultures, I know, and we’ll get results in twenty-four hours. I’m hearing all this secondhand. My job is to look after them.”
“Of course,” said Pia. “Has the CDC finished with the lab?”
“Dr. Springer said an hour ago that most of them were already headed back to Atlanta.”
Dr. De Silva’s cell phone beeped, and she glanced at a text message. “Oops, gotta go! Nice talking with you.”
“Can we see Dr. Rothman?”
“I don’t see any harm, but you’re not going to be seeing much,” Dr. De Silva said, already walking away. “As I said, he’s delirious. If you do go in, just make sure you put on all the gear and don’t bring anything out!”
Eagerly Pia set off toward Rothman’s room. George stumbled after her.
“What are you doing?” George complained. “You can’t go in there. He’s sick, he can’t tell you anything. Why take a chance?”
Pia didn’t answer. She suited up as per the Universal Precautions established by the CDC, which were posted on the outer door. George continued to try to talk Pia out of the visit, but she ignored him. He found a set of protective gear for himself and followed Pia into the room. As they passed through the door they could feel air entering with them.
Pia walked directly over to the bed. Several IVs were running, each laced with antibiotic.
“Dr. Rothman? . . . Dr. Rothman?”
Rothman stirred and half opened his eyes.
