The disease came close to Catherine and Paul in the spring of 1768 when Nikita Panin’s fiancee, Countess Anna Sheremeteva, described by a British diplomat as a woman of “uncommon merit, beautiful, and immensely rich,” was struck by smallpox. At Tsarskoe Selo, the empress waited anxiously. When, on May 5, she learned that Panin himself had been placed in quarantine for two weeks, she secretly ordered Paul brought to her. “I am very upset,” she said, “not being able to focus on anything better, for everything is awful in this critical situation.” Paul arrived at Tsarskoe Selo on May 6, and mother and son waited together. Catherine herself was ill on May 14 and better the next morning; she quickly informed Panin of her overnight recovery and passed along her doctor’s assurance that “these difficult days for your fiancee will pass.” Two days later she was told that Countess Sheremeteva was dead. “Having this hour learned of the demise of Countess Anna Petrovna, I could not help letting you know my real sorrow,” she wrote to Panin on May 17. “I am so touched for you by this grievous misfortune that I cannot sufficiently explain it. Please watch your own health.” She spent seven weeks at Tsarskoe Selo, and for the rest of the summer, she and Paul moved between country estates to avoid crowds.
• • •
Fear for herself, her son, and the nation prompted the empress to investigate a new, controversial method of inoculation that assured permanent immunity: the injection of matter taken from the smallpox pustules of a patient recovering from a mild case. This medical technique was being used in Britain and the British North American colonies (Thomas Jefferson was inoculated in 1766) but was shunned in continental Europe as being too dangerous.
Dr. Thomas Dimsdale was a Scot and a Quaker whose grandfather had accompanied William Penn to America in 1684. Thomas Dimsdale himself, now fifty-six, had a degree from Edinburgh University and had just published
Dimsdale was charmed by Catherine, finding her, “of all that I ever saw of her sex, the most engaging.” He was amazed by “her extreme penetration and the propriety of the questions she asked relative to the practice and success of inoculation.” The empress, in turn, liked his common sense, but in her opinion, he was overly cautious. She smiled at his stumbling French and tried to understand his English. She told him that she had feared smallpox all her life, but now she wished to be inoculated as the best way of overcoming the fears of others about the disease and about inoculation. She wanted to be inoculated as soon as possible. Dimsdale asked to first consult her court physicians, but Catherine said that this was unnecessary. Dimsdale then suggested that, as a trial measure, he should first innoculate other women of her age; again, Catherine said no. Bowed by the responsibility, Dimsdale begged her to wait a few weeks while he experimented on several local youngsters. She reluctantly agreed, on condition that he keep his preparations secret. The official court register ignored Dimsdale’s presence entirely, although the British ambassador reported on August 29 that the empress’s intention “is a secret everybody knows. And which does not seem to occasion much speculation.” Finally, the empress and the doctor agreed on a date for inoculation: October 12.
Catherine stopped eating meat and drinking wine ten days before this date and began taking calomel, powder of crab’s claws, and a tartar emetic. At nine in the evening on October 12, Dimsdale inoculated Catherine in both arms with smallpox matter taken from a peasant boy named Alexander Markov, whom she subsequently ennobled. The next morning, Catherine drove to Tsarskoe Selo for rest and isolation. She felt healthy “except for some slight uneasiness” and exercised outdoors for two or three hours a day. She developed a moderate number of pustules that dried up in a week. Dimsdale pronounced the inoculation a success, and three weeks later Catherine resumed her regular schedule. She returned to St. Petersburg on November 1, and Paul was inoculated without difficulty the next day. Congratulated by the Senate and the Legislative Commission, she responded, “My objective was, through my example, to save from death the multitude of my subjects who, not knowing the value of this technique, and frightened of it, were left in danger.”
Catherine’s example was followed by 140 of the St. Petersburg nobility, including Gregory Orlov, Kyril Razumovsky, and an archbishop. Dimsdale then went to Moscow and inoculated another fifty people. A Russian translation of his treatise explaining his technique was published in St. Petersburg, and inoculation clinics were established in St. Petersburg, Moscow, Kazan, Irkutsk, and other cities. By 1780, twenty thousand Russians had been inoculated; by 1800, two million. As a reward for his service, Catherine made Dimsdale a baron of the Russian empire and awarded him ten thousand pounds plus a life annuity of five hundred pounds. In 1781, Dimsdale returned to Russia to inoculate Catherine’s first grandson, Alexander.
Catherine’s willingness to be inoculated attracted favorable notice in western Europe. Voltaire compared what she had allowed Dimsdale to do with the ridiculous views and practices of “our argumentative charlatans in our medical schools.” At the time, the prevailing attitude toward the disease was fatalistic: people believed that, sooner or later, everyone must have it, and that some would survive and some would die. Most refused inoculation. Frederick of Prussia wrote to Catherine urging her not to take the risk. She replied that she had always been afraid of smallpox and wished more than anything to escape this fear. In May 1774, almost six years after Catherine was inoculated, smallpox killed the king of France. Louis XV took to bed a barely pubescent girl who was carrying smallpox. He died soon after, ending a reign of fifty-nine years. His successor, nineteen-year-old Louis XVI, was inoculated immediately.
• • •
Catherine’s personal confrontation with smallpox occurred three years before Russia was plunged into a desperate struggle with an even more terrible disease: bubonic plague. Plague was a perennial threat along the empire’s southern frontiers with European Turkey. It was believed to appear only in warm climates; the link with fleas and rats was unknown. The traditional defense was isolation, ranging from quarantine of suspected individual carriers to cordons of troops sealing off entire regions.
In March 1770, plague appeared among Russian troops occupying the Turkish Balkan province of Wallachia. In September, it reached Kiev, in the Ukraine. Cooler autumn weather slowed the advance of the disease, but by then, refugees were fleeing north. By mid-January 1771, the scare seemed over, but with the first spring thaw, Muscovites began to develop the distinctive dark spots and swollen glands. One hundred and sixty workers died in a single week at one textile factory in the city. On March 17, Catherine decreed emergency quarantine measures in Moscow: theatrical performances, balls, and all large public gatherings were banned. A sudden freeze at the end of March brought an abrupt decline in the death rate. Catherine and the municipal authorities began lifting restrictions. At the end of June, however, plague reappeared. By August, it was ravaging the city. Soldiers removing bodies from the streets fell ill and died. The city’s chief doctor requested medical leave for a month to receive treatment for his own illness. On September 5, Catherine was told that the daily death toll was between three and four hundred; that abandoned corpses littered the streets; that the network of checkpoints around the city was collapsing, and that the people were hungry because no supplies were being delivered. Men, women, and children already ill were required to enter quarantine centers.
The imposition of medical precautions led to rioting. Many in Moscow’s terror-stricken population came to believe that the physicians and their medicines had brought the plague to the city. They refused to obey orders forbidding them to gather in marketplaces and churches and to kiss supposedly miraculous icons in hope of protection. Instead, they gathered to seek salvation and solace around these icons. A famous icon of the Virgin at Varvarsky Gate became a magnet; day after day, crowds of diseased people swarmed around her feet. She became the deadliest center of contagion in the city.
