with the back of her hand. “This is the exact same sequence in a contemporary Palestinian woman,” Sana continued, handing the second page to Jack.
“And this sequence, which is also the same, is the mitochondrial sequence of Eve!” She gave Jack the final page. She was out of breath from excitement.
Jack looked up quizzically from the pages. “What do you mean the sequence of Eve?”
“It is a sequence that had been determined by a supercomputer running for weeks on end to determine the matrilineal most recent common ancestor, or MRCA,” Sana explained.
“In other words, it’s the sequence of the first female ancestor, taking into account every human permutation of the normal sixteen thousand and something base pairs of the human mitochondrial DNA sequence.”
“The statistics of something like that happening would be off the charts,” Jack said.
“Exactly. That’s why this is impossible.”
“What are you two mumbling about?” Shawn asked, coming up behind the others.
Sana gave Shawn the same explanation she’d given Jack. Shawn was equally dismissive.
“Something must have gone wrong with the system,” he suggested.
“I don’t think so,” Sana said. “I’ve done hundreds if not thousands of these MT
sequences. Nothing has ever gone wrong before. Why should something go wrong now?”
“Do you have any more of your sample from the PCR?” Jack asked.
“I do,” Sana replied.
“Why don’t you just run another sequencing and analysis?”
“Good idea,” Sana agreed.
“Wait a second,” Shawn said, holding up a hand. “Let me ask you two guys something, and then you tell me I’m crazy and to shut the hell up. Okay?”
“Okay,” both Sana and Jack said, nearly simultaneously.
“Okay,” Shawn said. “Here’s the only way that this statistically impossible situation could have occurred. . . .” Shawn hesitated, looking back and forth from Sana to Jack.
“All right, already. Tell us!” Sana protested. Her pulse was still racing.
“We’re all ears,” Jack agreed. “Shoot!”
“Are you sure you’re ready?” Shawn teased, to good effect.
“I’m going back into the lab to run another sample,” Sana said, pushing away from the counter where she’d been leaning.
“Wait!” Shawn said, catching her arm. “I’ll tell you, promise!”
“I’ll give you five seconds to start or I’m going into the lab,” Sana said. She’d had enough. She wasn’t going to play Shawn’s game any longer. She was too excited.
“For a second forget the Palestinian woman. We have two identical samples: matrilineal Eve and the woman from the ossuary. Other than having the same mitochondrial DNA, what makes them similar?”
Sana glanced at Jack, who returned her stare. “They weren’t contemporaries, if that’s what you are implying,” Sana said. “Matrilineal Eve is projected back many hundreds of thousands of years.”
“No, no,” Shawn said. “Their similarity is not that. Let me put it another way. My belief, thanks to Saturninus’s letter, is that the bones in the ossuary are those of Mary, the Mother of Jesus of Nazareth. Let’s assume for a moment they are, which would make them extraordinarily holy objects to many, many people. Do you follow me so far?”
“Of course,” Sana said impatiently.
“Now, if we had some bones from matrilineal Eve here as well, how would they be similar, besides having the same mitochondrial DNA sequence?”
“Perhaps they’d have the same nuclear DNA sequence as well,” Jack suggested.
“Maybe, but that’s not what I want to hear,” Shawn said, as impatient as Sana. “Think from a theological perspective!”
Jack shook his head while looking at Sana. She shook her head as well. “You are going to have to tell us what you want to hear.”
“Theologically, they were both made directly by God the Father. Remember the Catholic feast James mentioned to us this past Sunday that he celebrated? It was the Feast of the Immaculate Conception, which was about the creation of Mary to be the sinless Mother of Christ. Well, Eve was also sinless at first. As the first female, there was no one else around to create her but God himself. Now, how many recipes, so to speak, do you think God might have for humans? My guess would be one, and in terms of mitochondrial DNA sequence, what we have here is
Both Sana and Shawn laughed gleefully and then hugged despite Sana’s barrier gown, hat, gloves, and booties. “Our journal articles are going to be classics even before their publications,” Shawn blurted. He then broke away from Sana. “I have to get to work!
I’m not sure if I’ll be able to wait to finish all three scrolls. I’ve never been more excited in my life about a couple of papers.”
“I’m going to run several more samples, just to be totally sure of the results,” Sana announced.
“And while you guys do that,” Jack said, getting to his feet, “I’m going to head home somewhat early to insist my wife take a break.” Actually, Jack had something more specific in mind. He’d called the pediatric oncologist that morning who was in charge of the neuroblastoma protocol at Memorial to ask, in light of JJ’s several good days, if Jack should bring the boy in for blood work to check his level of mouse antibody.
“Congratulations,” Jack called out as he opened the door to the hall. Both Shawn and Sana waved in response. Sana was at that moment heading back into the gowning room to regown. Shawn was back at the painstaking unrolling work. “What time in the morning?” Jack yelled out.
“Let’s say ten,” Shawn yelled back. “There may be some celebrating tonight.”
“By the way,” Jack yelled, “I’d hold off telling James about the mito DNA until it’s confirmed.”
“That’s probably the merciful thing to do,” Shawn agreed.
Jack was about to leave when he thought of something else. Since yelling from the doorway was potentially disturbing to others in the lab, he returned to the office and approached Shawn. Jack could see Sana in the gowning room in the middle of changing.
“I forgot about the Palestinian woman that also matched,” Jack said. “What on earth does that say?”
“Good question,” Shawn said, rolling back his chair. He quickly stuck his head into the gowning room and asked Sana her opinion.
“She has to be a direct matrilineal relative of the woman in the ossuary,” Sana said. “It’s possible, because the half-life for a single nucleotide mutation or SNP for mitochondrial DNA is two thousand years. That would be my guess,” Sana said, completing her dressing.
“Did you hear that?” Shawn asked Jack, letting the gowning-room door close.
“I did,” Jack said. “It’s curious to think about. I wonder if she has any idea, or if anyone had an idea. It even makes me wonder if she’s a Christian or a Muslim.”
“Maybe one of us should look her up sometime,” Shawn said, “although I can’t help but have the feeling the less she was told, the better.”
“It’s a curious idea,” Jack said. He then took his leave for the second time. As he rode down in the elevator, another associated thought passed through his mind. One aspect of alternative medicine he had not even touched on was faith healing, and the reason was that he gave it even less chance of being efficacious than some of the other methods. A few times, while idly channel surfing on the television in his old life, he’d briefly watched as TV evangelists put their hands on supposed patients’ foreheads, which would cause the people to fall back, limp yet cured. Yet if someone had the same DNA as the Mother of Jesus of Nazareth, Jack couldn’t help but wonder if she could heal others.
The elevator reached the first floor, and Jack got off. Almost immediately, thoughts about faith healing evaporated from his mind, replaced by thoughts concerning the antibody levels in JJ’s body.
29
4:44 P.M., WEDNESDAY, DECEMBER 10, 2008
