The shrill debate never affected my decisions. I read a lot of history, and I was struck by how many presidents had endured harsh criticism. The measure of their character, and often their success, was how they responded. Those who based decisions on principle, not some snapshot of public opinion, were often vindicated over time.

George Washington once wrote that leading by conviction gave him “a consolation within that no earthly efforts can deprive me of.” He continued: “The arrows of malevolence, however barbed and well pointed, never can reach the most vulnerable part of me.”

I read those words in Presidential Courage, written by historian Michael Beschloss in 2007. As I told Laura, if they’re still assessing George Washington’s legacy more than two centuries after he left office, this George W. doesn’t have to worry about today’s headlines.

Far from the yelling on the TV sets and the campaign trail, my stem cell policy quietly moved forward in the labs. For the first time in history, scientists received federal grants to support embryonic stem cell research.

Scientists also used new federal funding for alternative stem cell research to explore the potential of adult bone marrow, placentas, amniotic fluid, and other non-embryonic sources. Their research yielded new treatments for patients suffering from dozens of diseases—free of moral drawbacks. For example, doctors discovered a way to collect stem cells harmlessly from the blood of umbilical cords to treat patients suffering from leukemia and sickle- cell anemia.

Much of this research was overseen by Dr. Elias Zerhouni, the talented Algerian American I appointed to lead the NIH. I had put Elias in a tough position. He felt trapped between a president he had agreed to serve and the scientific community of which he was part. He did not agree with my embryonic stem cell policy. Yet he was more interested in new cures than in politics. He funded the alternative stem cell sources aggressively, and a good deal of credit for the breakthroughs in the field belongs to Dr. Zerhouni and his team of professionals at the NIH.

Unfortunately, most members of Congress paid more attention to politics than to the scientific discoveries. As the 2006 elections approached, Democrats made clear they would again use the issue as a political weapon. A U.S. Senate candidate in Missouri persuaded Michael J. Fox, who suffers from Parkinson’s, to attack her opponent in statewide TV ads. Some Republicans who had initially supported the policy feared for their seats and changed their minds. In July 2006, the House and Senate considered a bill that would overturn my stem cell policy by permitting federal funding for research that destroyed human life.

Five and a half years into the presidency, I had yet to veto a piece of legislation. I had worked closely with our congressional majorities to pass bills I could accept. But as the stem cell bill was working its way through Congress, I had made clear I would veto it. When it reached my desk, I did.

I was hit with all sorts of labels, “stubborn” being one of the most polite. But I would not change my position. If I abandoned my principles on an issue like stem cell research, how could I maintain my credibility on anything else?

I thought a lot about how to send the right signal about the veto. I wanted a vivid way to show that my position was grounded in my reverence for life, not any aversion to science. When Karl Zinsmeister, my domestic policy adviser, suggested inviting a group of snowflake babies to the White House, I thought the idea was perfect. Each had come from a frozen embryo that, rather than being destroyed for research, was implanted in an adoptive mother.

I gave my veto speech in the East Room with twenty-four excited children and their parents onstage. One of the little wigglers was fourteen-month-old Trey Jones. He started life as an embryo fertilized by Dave and Heather Wright of Macomb, Michigan. The couple had undergone IVF treatment, which helped them bring three beautiful children into the world. They gave permission for their remaining frozen embryos to be adopted, instead of being destroyed for research.

Holding Trey Jones. White House/Kimberlee Hewitt

In Cypress, Texas, J.?J. and Tracy Jones were praying for a child. Through Nightlight Christian Adoptions, they were paired with the Wright family embryos. The result was the smiling, blond-haired boy named Trey whom I held in my arms at the White House. Thanks to the miracle of science and the compassion of two families, Trey had a loving home and a hopeful life ahead of him.

A few weeks after the event, I received a touching letter from J.?J. Jones. He described the “pain of infertility” and how blessed he and Tracy felt to have their “precious Trey who some describe as a leftover destined to be either destroyed or used for research.” He also informed me that Trey would soon have a sibling, the product of another frozen embryo he and Tracy had adopted.

Congress’s response to my veto was not so warm. The Democratic sponsor of the bill erupted with a statement claiming that my veto was based on “cynical political gain.” It was hard to see how, since most polls showed my stem cell stance was not popular. As punishment for my veto, Democrats refused to pass legislation supporting research into alternative sources of stem cells. The message was that if they couldn’t fund stem cell research that destroyed embryos, they would prefer to fund none at all. So much for their passionate desire to see new cures.

When Democrats won control of the House and Senate, they decided to make another run at overturning my policy. Speaker Nancy Pelosi announced that it was one of her top priorities. They sent me another bill in June 2007; I sent it back again with my veto. Thanks to the courage of many Republicans on Capitol Hill, the veto held.

Five months later, Americans awoke to an unexpected headline on the front page of the New York Times: “Scientists Bypass Need for Embryo to Get Stem Cells.” The article described how two teams of researchers, one in Wisconsin and one in Japan, had reprogrammed an adult skin cell to behave like an embryonic stem cell. By adding just four genes to the adult cell, scientists were able to replicate the medical promise of embryonic stem cells without moral controversy.

The discovery reverberated throughout the scientific community. Fervent advocates of embryonic stem cell research hailed the breakthrough as “a spectacular advance” and “ethically uncomplicated.” Ian Wilmut, the Scottish scientist who cloned Dolly the sheep, announced that he would no longer pursue the cloning of human embryos, but would instead use this new technique.

I was thrilled by the news. This was the scientific breakthrough that I had hoped for when I made my announcement in 2001. Charles Krauthammer, one of the most insightful columnists in America and a respectful critic of my stem cell decision in 2001, wrote, “The verdict is clear: Rarely has a president—so vilified for a moral stance—been so thoroughly vindicated.”

In the years to come, our nation will face more dilemmas about bioethics, from cloning to genetic engineering. History will judge the character of our country in large part by the way we answer these challenges to human dignity. I have faith, as I did when I announced my stem cell decision in 2001, that science and ethics can coexist. With thoughtful policy, we can usher in the new cures that Nancy Reagan hoped for, without moving toward the world foreseen by Aldous Huxley.

After my address to the nation on stem cell research in August 2001, several commentators called it the most important decision of my presidency. That was true at the time, but not for long.

*The famous actor who played Superman, Reeve was confined to a wheelchair after a horse-riding accident. Sadly, he died in October 2004, one day before Edwards’s statement.

n Tuesday, September 11, 2001, I awoke before dawn in my suite at the Colony Beach and Tennis Resort near Sarasota, Florida. I started the morning by reading the Bible and then went downstairs for a run. It was pitch-black as I began my jog around the golf course. The Secret Service agents had grown accustomed to my exercise routine; the locals must have found this run in the dark a little bizarre.

Back at the hotel, I took a quick shower, ate a light breakfast, and skimmed the morning papers. The biggest story was that Michael Jordan was coming out of retirement to rejoin the NBA. Other headlines focused on the New York mayoral primary and a suspected case of mad cow disease in Japan.

Around 8:00 a.m., I received the Presidential Daily Briefing. The PDB, which combined highly classified intelligence with in-depth analysis of geopolitics, was one of the most fascinating parts of my day. The September

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