was among the greatest medical achievements of the twentieth century.”
Now, at Vector, Popov urged Sandakhchiev to consider smallpox for reengineering in Project Factor, instead of re-creating SV40 or making artificial viruses. Why not invent something new out of smallpox? Smallpox was simple to grow, easily aerosolized, caused a disease with a high mortality and was stable in storage.
Popov did not at this point work directly on the dangerous smallpox virus, but used models with related viruses, such as
As he began trying to manipulate some microbes, Popov faced a serious difficulty. It was hard to get organisms to increase the amount of toxin they discharged. They could emit a small amount, but if he tried to make them more productive, there was an unexpected side effect: the microbe became less poisonous. The virulence of the organism would decline, instead of increasing. “If we made them good producers,” he said, “we often ended up with poor killers.” Through years of work, Popov searched for a solution.
His work eventually took him in a slightly different direction. Working with others, he found a way to set off a biological trigger, or switch, to deceive the body’s immune system. Normally, when there’s a disease, the body attacks it. But in this new concept, if the microbe is made to appear similar to the human body, the immune system would be triggered not only against the invader, but to attack the healthy person, to turn on itself. This made the genetically engineered organism a powerful killer—without having to produce more of the poison.
“The idea was to subvert the natural regulation of the human body and direct it against itself,” Popov explained to me. “All this would require only a biological switch, or signal, which the body is expected to follow.”
The body’s immune system could be fooled to attack the body itself.
There were different possible targets considered in the research, Popov said, but a decision was made to have the immune system turn against the body’s nervous system. Thus, if developed into a real weapon, it would cause victims to suffer in two waves. The first might be smallpox. But then, perhaps after a period of recovery, the body would turn on its own nervous system, and the victims would be paralyzed and die. The second wave would be unexpected; no vaccine could stop the process. “As a weapon, the thing would be absolutely untreatable,” he said. “Absolutely untreatable, because first of all it may come as a surprise after the initial disease has gone away, the person may recover completely. And then the new wave of disease would be the death response…”
In 1985, Popov built what is known as the “construct” of his idea, a piece of DNA that would be inserted somewhere into a genome. It was only the start, but it was significant enough that Sandakhchiev no longer needed the earlier proposal to manufacture large quantities of artificial DNA. They could make the deadly agents with just small bits of genetic material. And it became clear that a whole new generation of agents for potential use in weapons was beckoning.
At Koltsovo, scientists like Popov broke through barriers of knowledge, but building actual weapons was the job of the military, which maintained its own separate laboratories. Vector was a research facility. The “customer” was the 15th Main Directorate of the Ministry of Defense. Periodically, the customer came to visit Vector, to check on progress. And there was finally something to tell them.
Secluded in the forests outside of Moscow, another scientist was fighting his own battle. While Vector sought to alter viruses, Igor Domaradsky attempted to reengineer the genetic makeup of bacteria into an unstoppable warrior. Domaradsky walked with a slight limp; he had suffered polio as a child, and tuberculosis and malaria as an adult. He had a reputation for being irritable, hard to contain, and he later called himself a troublemaker, an inconvenient man. He was always restless. He yearned for the rewards of scientific discovery but worked in service of weapons of death.8
In 1984, he was fifty-nine years old. During the week, he lived alone in Protvino, a small town one hundred miles south of Moscow. He drove through the mixed forests of birch and bogs each day to start work at a secret laboratory. The location was called Obolensk, after ancient princes who once ruled the forests. He was fond of the drive, and often, in winter, came face-to-face with roaming elk. He remembered when Obolensk was carved out of the woods. At first, there were temporary “huts,” long, crude one-story barracks for researchers. By the early 1980s, the modern Korpus No. 1 rose out of the forest. Outwardly, it appeared to be another eight-story, boxy Soviet office building. But inside it was 400,417 square feet dedicated to the study and manipulation of dangerous pathogens. The third floor was devoted to especially hazardous materials. Massive airlocks and seals guarded against leaks.9 Obolensk itself was dark and marshy, and Domaradsky considered it a privilege to have his apartment ten miles to the south in Protvino, in the fresh air near the banks of the Oka River.
The laboratory at Obolensk was known as Post Office Box V-8724, one of dozens of closed Soviet cities and laboratories devoted to Cold War military work.10 Domaradsky worked in the laboratory during the week, living in his Protvino apartment, and drove two hours back to Moscow to see his family on weekends, sometimes lingering in the city on Monday. His wife, Svetlana Skvortsova, was a talented actress and teacher who thrived in Moscow’s rich cultural life. Domaradsky worked in lonesome isolation.
The enforced solitude caused him to ponder all that he had done. In the apartment, he began collecting papers and hiding notes of his life’s work, making illicit photocopies so the evidence of his achievements would not be destroyed by the secret services that watched over him.
On weekday mornings, Domaradsky switched on the radio in his apartment to listen to Radio Free Europe, the BBC and Deutsche Welle, the German broadcaster, which were easier to receive in the countryside than in the big cities. “Nobody bothered me, and I luxuriated in my freedom to listen to foreign radio, learning a great deal of news about the USSR and the world that was not available in Moscow.” He would then put on a record of his favorite music. Sometimes he went skiing, in the mornings or evenings after work, through a park and forest. Food shortages were common, but Domaradsky was permitted to shop at the small elite “Ryabinka” grocery store for directors of a nearby physics institute. While Soviet citizens were in lines for the basics, the store carried such rare commodities as instant coffee and caviar, delivering them to his door and taking his order for the next delivery. He felt well off, but his science was difficult, and its goals, he knew, were dreadful.
Tularemia, commonly known as “rabbit fever,” is caused by a bacterium that is highly infectious. It is formally known as
In general, the Soviet military preferred to use contagious pathogens like the smallpox virus and plague because they could cause epidemics. The military would simply light the spark, and the disease would spread like wildfire on its own. Tularemia is not contagious, and thus cannot be passed from human to human. Yet the military retained interest in tularemia because it required as few as ten microorganisms inhaled or ingested to infect someone.11 Tularemia is also stable and easy to aerosolize; the microorganism can survive for weeks at low temperatures.
Unlike viruses, which are nothing more than a few genes and protein, with perhaps a membrane, bacteria live inside rigid outer walls. The wall is critical to the cell’s survival, giving it structure and support. Without it, the cell dies. In the 1930s and 1940s, antibiotics were developed that could attack bacteria; the first was penicillin. These drugs could slow or even kill the bacteria in several ways: weaken the cell wall, inhibit its growth or stop its replication. Antibiotics helped defeat infections that have threatened man through the centuries. Diseases such as rheumatic fever, syphilis and bacterial pneumonia became easily treatable. These miracle medicines held promise that some diseases could be wiped out. By the 1940s, there were dozens of antibiotics, but then came another twist: bacteria acquired resistance to them. Within a few years, many of the powerful wonder drugs were losing their efficacy. The remaining bacteria were no longer vulnerable to antibiotics, as a result of natural selection— those which were genetically able to resist the drugs had survived. Over time only the resistant bacteria remained, and the drugs lost their effectiveness.12
The goal of Domaradsky’s research was to build a new microbe that would be resistant to many antibiotics.
