Trends in Genetics 13: 323—9.

12. Cassidy, S. B. (1995). Uniparental disomy and genomic imprinting as causes of human genetic disease. Environmental and Molecular Mutagenesis 25, Suppl. 26: 13-20; Kishino, T. and Wagstaff, J. (1998). Genomic organisation of the UBE3A/E6-AP gene and related pseudogenes. Genomics 47: 101—7.

13. Jiang, Y., Tsai, T.-F., Bressler, J. and Beaudet, A. L. (1998). Imprinting in Angelman and Prader-Willi syndromes. Current Opinion in Genetics and Development 8: 334—42.

14. Allen, N. D., Logan, K., Lally, G., Drage, D. J., Norris, M. and Keverne, B I B L I O G R A P H Y A N D N O T E S 3 3 1

E. B. (1995). Distribution of pathenogenetic cells in the mouse brain and their influence on brain development and behaviour. Proceedings of the National Academy of Sciences of the USA 92: 10782—6; Trivers, R. and Burt, A. (in preparation), Kinship and genomic imprinting.

15. Vines, G. (1997). Where did you get your brains? New Scientist, 3 May 1997: 34-9; Lefebvre, L., Viville, S., Barton, S. C, Ishino, F., Keverne, E. B. and Surani, M. A. (1998). Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nature Genetics 20: 163—9.

16. Pagel, M. (1999). Mother and father in surprise genetic agreement. Nature 397: 19-20.

17. Skuse, D. H. et al. (1997). Evidence from Turner's syndrome of an imprinted locus affecting cognitive function. Nature 387: 705—8.

18. Diamond, M. and Sigmundson, H. K. (1997). Sex assignment at birth: long-term review and clinical implications. Archives of Pediatric and Adolescent Medicine 151: 298-304.

C H R O M O S O M E 1 6

There are no good popular books on the genetics of learning mechanisms.

A good textbook is: M. F. Bear, B. W. Connors and M. A. Paradiso's Neuroscience: exploring the brain (Williams and Wilkins, 1996).

1. Baldwin, J. M. (1896). A new factor in evolution. American Naturalist 30: 441-51, 536-53.

2. Schacher, S., Castelluci, V. F. and Kandel, E. R. (1988). cAMP evokes long-term facilitation in Aplysia neurons that requires new protein synthesis.

Science 240: 1667—9.

3. Bailey, C. H., Bartsch, D. and Kandel, E. R. (1996). Towards a molecular definition of long-term memory storage. Proceedings of the National Academy of Sciences of the USA 93: 12445 — 52.

4. Tully, T., Preat, T., Boynton, S. C. and Del Vecchio, M. (1994). Genetic dissection of consolidated memory in Drosophila. Cell 79: 39-47; Dubnau, J. and Tully, T. (1998). Gene discovery in Drosophila: new insights for learning and memory. Annual Review of Neuroscience 21: 407—44.

5. Silva, A. J., Smith, A. M. and Giese, K. P. (1997). Gene targeting and 3 3 2 G E N O M E

the biology of learning and memory. Annual Review of Genetics 31: 527—46.

6. Davis, R. L. (1993). Mushroom bodies and Drosophila learning.

Neuron 11: 1-14; Grotewiel, M. S., Beck, C. D. O., Wu, K. H., Zhu, X.-R.

and Davis, R. L. (1998). Integrin-mediated short-term memory in Drosophila.

Nature 391: 455—60.

7. Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van-Paesschen, W. and Mishkin, M. (1997). Differential effects of early hippo¬

campal pathology on episodic and semantic memory. Science 277: 376—80.

C H R O M O S O M E 1 7

The best recent account of cancer research is Robert Weinberg's One renegade cell (Weidenfeld and Nicolson, 1998).

1. Hakem, R. et al. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339—52.

2. Ridley, M. (1996). The origins of virtue. Viking, London; Raff, M. (1998).

Cell suicide for beginners. Nature 396: 119-22.

3. Cookson, W. (1994). The gene hunters: adventures in the genome jungle. Aurum Press, London.

4. Sunday Telegraph, 3 May 1998, p. 25.

5. Weinberg, R. (1998). One renegade cell. Weidenfeld and Nicolson, London.

6. Levine, A. J. (1997). P53, the cellular gatekeeper for growth and division.

Cell 88: 323-31.

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