Matt Ridley

Trends in Genetics 13: 125-7; Fernandez-Canon, J. M. and Penalva, M. A.

(1995). Homogentisate dioxygenase gene cloned in Aspergillus. Proceedings of the National Academy of Sciences of the USA 92: 9132-6.

3 I 8 G E N O M E

C H R O M O S O M E 4

For those concerned about inherited disorders such as Huntington's disease, the writings of Nancy and Alice Wexler, detailed in the notes below, are essential reading. Stephen Thomas's Genetic risk (Pelican, 1986) is a very accessible guide.

1. Thomas, S. (1986). Genetic risk. Pelican, London.

2. Gusella, J. F., McNeil, S., Persichetti, F., Srinidhi, J., Novelletto, A., Bird, E., Faber, P., Vonsattel, J . P . , Myers, R. H. and MacDonald, M. E. (1996).

Huntington's disease. Cold Spring Harbor Symposia on Quantitative Biology 61: 615—26.

3. Huntington, G. (1872). On chorea. Medical and Surgical Reporter 26: 3 1 7 - 2 1 .

4. Wexler, N. (1992). Clairvoyance and caution: repercussions from the Human Genome Project. In The code of codes (ed. D. Kevles and L. Hood), pp. 211-43. Harvard University Press.

5. Huntington's Disease Collaborative Research Group (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72: 971— 83.

6. Goldberg, Y. P. et al. (1996). Cleavage of huntingtin by apopain, a proapop-totic cysteine protease, is modulated by the polyglutamine tract. Nature Genetics 13: 442-9; DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P. and Aronin, N. (1997). Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277: 1990-93.

7. Kakiuza, A. (1998). Protein precipitation: a common etiology in neurodegenerative disorders? Trends in genetics 14: 398—402.

8. Bat, O., Kimmel, M. and Axelrod, D. E. (1997). Computer simulation of expansions of DNA triplet repeats in the fragile-X syndrome and Huntington's disease. Journal of Theoretical Biology 188: 53—67.

9. Schweitzer, J. K. and Livingston, D. M. (1997). Destabilisation of CAG

trinucleotide repeat tracts by mismatch repair mutations in yeast. Human Molecular Genetics 6: 349—55.

10. Mangiarini, L. (1997). Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation. Nature Genetics 15: 197-200; Bates, G. P., Mangiarini, L., Mahal, A. and Davies, S. W. (1997).

B I B L I O G R A P H Y A N D N O T E S 3 1 9

Transgenic models of Huntington's disease. Human Molecular Genetics 6: 1633- 7.

11. Chong, S. S. et al. (1997). Contribution of DNA sequence and CAG

si2e to mutation frequencies of intermediate alleles for Huntington's disease: evidence from single sperm analyses. Human Molecular Genetics 6: 301 — 10.

12. Wexler, N. S. (1992). The Tiresias complex: Huntington's disease as a paradigm of testing for late-onset disorders. FASEB Journal 6: 2820-25.

13. Wexler, A. (1995). Mapping fate. University of California Press, Los Angeles.

C H R O M O S O M E 5

One of the best books about gene hunting is William Cookson's The gene hunters: adventures in the genome jungle (Aurum Press, 1994). Cookson is one of my main sources of information on asthma genes.

1. Hamilton, G. (1998). Let them eat dirt. New Scientist, 18 July 1998: 26—

31; Rook, G. A. W. and Stanford, J. L. (1998). Give us this day our daily germs. Immunology Today 19: 113—16.

2. Cookson, W. (1994). The gene hunters: adventures in the genome jungle. Aurum Press, London.

3. Marsh, D. G. et al. (1994). Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin-E concentrations. Science 264: 1152—6.

4. Martinez, F. D. et al. (1997). Association between genetic polymorphism of the beta-2-adrenoceptor and response to albuterol in children with or without a history of wheezing. Journal of Clinical Investigation 100: 3184-8.

C H R O M O S O M E 6

The story of Robert Plomin's search for genes that influence intelligence will be told in a forthcoming book by Rosalind Arden. Plomin's textbook on Behavioral genetics is an especially readable introduction to the field (third edition, W. H. Freeman, 1997). Stephen Jay Gould's Mismeasure of man 3 2 0 G E N O M E

(Norton, 1981) is a good account of the early history of eugenics and IQ.

Lawrence Wright's Twins: genes, environment and the mystery of identity (Weidenfeld and Nicolson, 1997) is a delightful read.